Pulmonary Hypertension Drugs Market SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2024 - 2031)

Pulmonary Hypertension Drugs Market is segmented By Stages (Phase-III, Phase-II, Phase-I, Preclinical, Discovery), By Route of Administration (Oral, Intravenous,, Subcuta ....

Pulmonary Hypertension Drugs Market Size

Market Size in USD Bn

CAGR7.12%

Study Period2024 - 2031
Base Year of Estimation2023
CAGR7.12%
Market ConcentrationHigh
Major PlayersTenax Therapeutics, Atgeno AB, Bayer, Bellerophon Therapeutics, United Therapeutics and Among Others.
*Disclaimer: Major players are listed in no particular order.
*Source: Coherent Market Insights
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Pulmonary Hypertension Drugs Market Analysis

The Global Pulmonary Hypertension Drugs Market is estimated to be valued at USD 8.10 Bn in 2024 and is expected to reach USD 15.2 Bn by 2031, growing at a compound annual growth rate (CAGR) of 7.12% from 2024 to 2031. The market is majorly driven by the increasing prevalence of pulmonary hypertension disease globally and launch of novel drugs to treat the condition.

The market is witnessing positive trends with strong product pipeline and launch of innovative drugs to treat pulmonary hypertension. Furthermore, the growing awareness about available treatment options and government support are supporting the adoption of pulmonary hypertension drugs in the market. However, high treatment cost and lack of disease-specific guidelines in some regions may hinder the market growth during the forecast period.

Pulmonary Hypertension Drugs Market Trends

Market Driver - Rising Awareness and Improved Diagnostic Methods Leading to Earlier Detection of Pulmonary Hypertension.

With increased awareness about symptoms and risk factors associated with pulmonary hypertension, a high number of people are getting themselves screened regularly. Pulmonary hypertension is usually difficult to diagnose at an early stage as symptoms are vague and non-specific. However, recent diagnostic advancements such as right heart catheterization and echocardiography have enabled accurate detection and classification of disease even at mild or moderate stages. This has significantly improved survival rates as patients can now seek treatment much before the condition progresses to later stages. Numerous non-profit organizations and advocacy groups are also educating general public and healthcare providers through various awareness programs. They educate people on recognising early warning signs of the disease and emphasise importance of timely medical advice. All these efforts have collectively contributed towards identifying more PH patients and allowing them to access life-prolonging therapies in a timely manner. As a result of early detection, the target population suitable for currently available treatment options has expanded. This acts as a major growth driver for pharmaceutical companies manufacturing approved drugs for pulmonary hypertension.

Market Driver - A Strong Pipeline with Novel Therapies That Target Multiple Pathways, Such as Vasodilators and Gene Therapies.

The pulmonary hypertension treatment landscape is evolving at a rapid pace with many novel molecules in different stages of clinical trials. Major focus is on developing oral therapies that work through novel mechanisms of action and pathways. Several drug candidates are under investigation that act as vasodilators by directly targeting pathways involved in smooth muscle cell proliferation and pulmonary artery constriction. Gene and cell-based therapies are also being researched which can potentially provide long term benefit by correcting the underlying genetic deficiencies seen in certain types of PH. A few therapies are exploring angiogenesis and mobilization of stem cells for repairing damaged pulmonary vasculature. A wave of pipeline drugs gaining approvals in the coming years will generate many fresh treatment options with improved safety profiles. This robust pipeline helps sustain the enthusiasm of medical community as well as patients. Availability of promising investigational therapies keeps stakeholders hopeful about finding more effective long term solutions that could slow disease progression and improve outcomes. Such a vibrant clinical development activity augurs well for the overall pulmonary hypertension market.

Pulmonary Hypertension Drugs Market Key Factors

Market Challenge - The High Cost of Treatment, Especially with Novel Therapies Like Gene Therapy and Monoclonal Antibodies.

The high cost of treatment, especially with novel therapies like gene therapy and monoclonal antibodies poses a major challenge for the pulmonary hypertension drugs market. Developing new drugs and therapies using cutting edge technologies like gene therapy require massive investments in research and clinical trials over many years. This adds significantly to the overall cost of successful new drug launches. Moreover, since pulmonary hypertension is a rare disease with a relatively small patient pool worldwide, the development costs cannot be recouped quickly. As a result, novel drugs for pulmonary hypertension often enter the market with annual price tags of over USD100,000 per patient. The financial burden of such expensive therapies makes them inaccessible to many patients. Insurance companies and governments find it difficult to provide coverage and reimbursement for high-cost drugs. This economic hurdle reduces the uptake of innovative new treatments and hence limits the market potential and growth opportunities for drug makers.

Market Opportunity: Increasing Research into Gene Therapy and Advanced Biologics.

Increasing research into gene therapy and advanced biologics to target pulmonary hypertension more effectively offers promising opportunities for market growth. Scientists are exploring novel gene therapy approaches that could potentially cure pulmonary hypertension by correcting the underlying genetic defects. Several biotechs and pharmaceutical companies are actively conducting clinical trials of gene therapies delivered via viral vectors. At the same time, monoclonal antibodies and other biologic drugs are being developed that can better regulate pathways involved in pulmonary artery constriction and remodelling. If successful, such advanced modalities could revolutionise treatment by achieving superior efficacy than existing drugs with durability of response. Their ability to deliver long-lasting benefits in a single course of treatment also addresses the compliance challenges with daily oral regimens. As research progresses, newer biologics and gene therapies are expected to enter the market in the coming years, driving higher spending and expanding the pulmonary hypertension drugs market size significantly.

Prescribers preferences of Pulmonary Hypertension Drugs Market

Pulmonary Hypertension (PH) can be classified into five stages based on the mean pulmonary arterial pressure (mPAP) and cardiac output. Initial treatment typically starts with Group 1 PH medications during Stages 1-3 when mPAP is 25-40 mmHg. Endothelin receptor antagonists (ERAs) such as bosentan (Tracleer) and ambrisentan (Letairis) are often first-line options due to favorable risk-benefit profiles. Phosphodiesterase type-5 inhibitors (PDE-5i) like sildenafil (Revatio) and tadalafil (Adcirca) are also commonly prescribed.

As the disease progresses into Stage 3, dual combination therapy with ERAs and PDE-5i becomes more prevalent to achieve better symptomatic relief. Medications such as riociguat (Adempas), a soluble guanylate cyclase stimulator, start gaining popularity as an add-on drug due to its novel mechanism of action.

For patients in advanced Stages 4-5 with mPAP over 40 mmHg, prostanoids like epoprostenol (Flolan), treprostinil (Tyvaso), and iloprost (Ventavis) provide the most vasodilatory effect and hence, better survival benefits. However, due to their parenteral routes of administration and associated side effects, prostanoids are generally reserved for later lines of treatment.

Hemodynamics, functional status, and adherence also impact drug selection. Overall, prescribers prefer initial oral options but ultimately aim to optimize treatment by balancing efficacy, tolerability, administration convenience and other individual factors.

Treatment Option Analysis of Pulmonary Hypertension Drugs Market

Pulmonary hypertension has four stages based on symptoms and hemodynamics. Stage I involves mild symptoms with a mean pulmonary artery pressure (mPAP) of 25-30 mmHg at rest. Stage II shows moderate limitations with an mPAP of 31-35 mmHg.

Stage III features severe symptoms with an mPAP of 36-45 mmHg. End-stage/stage IV has very poor prognosis with an mPAP over 45 mmHg.

For stage I, medications like Endothelin receptor antagonists (ERAs) such as ambrisentan (Letairis) or macitentan (Opsumit) are preferred. They work by blocking receptors that cause constriction of blood vessels in the lungs.

Stage II is often treated with prostacyclin analogs like iloprost (Ventavis), treprostinil (Tyvaso), or selexipag (Uptravi). These work directly on the prostacyclin receptor in the lungs to relax vessels.

Stage III may require combining therapies like adding a phosphodiesterase type-5 inhibitor like tadalafil (Adcirca) to an ERA.

Stage IV has a poor prognosis despite treatment. Combinations are used but lung transplantation is the only intervention that prolongs life. Several drug classes in combination are needed to treat more advanced stages due to the complex pathophysiology involved. Selection depends on symptoms, hemodynamics and tolerability for each individual patient.

Key winning strategies adopted by key players of Pulmonary Hypertension Drugs Market

Drug Innovation Through R&D: Developing novel drugs has been a crucial strategy adopted by leading players to gain a competitive edge. For example, Actelion (now Janssen) launched Opsumit (macitentan) in 2013, the first oral endothelin receptor antagonist (ERA) approved for pulmonary arterial hypertension (PAH). Opsumit was a major breakthrough as it offered improved efficacy and safety over existing ERAs. Its approval and commercial success helped Actelion strengthen its leadership position in the PAH market.

 Targeted Acquisitions: Strategic acquisitions of smaller firms working on new drugs/technologies have reinforced product pipelines.

Commercial Excellence: Leaders invest heavily in specialized sales and marketing teams to drive prescription volumes. For example, Janssen and United Therapeutics deploy a field force of over 200 sales representatives solely dedicated to engage pulmonary specialists. Additionally, patient support programs and nursing services have improved treatment adherence.

The above examples show that combinations of innovative R&D, prudent M&A activity, and exemplary commercialization have enabled companies to introduce multiple novel drugs and capture the majority market share in pulmonary hypertension over the past two decades.

Segmental Analysis of Pulmonary Hypertension Drugs Market

Insights, By Stages, Phase-III is leading Due to Advancing Development Leads to Market Dominance in the Coming Years.

By Stages, Phase-III is expected to contribute the highest share 45.9% in 2024 owing to the extensive development undergone by drugs in this stage. Drugs in Phase-III have proven their efficacy and safety profile based on preliminary clinical trials involving larger human populations. Extensive testing allows manufacturers to identify and address any issues, refine dosage regimens, evaluate long-term effects and comparative effectiveness. This rigorous validation gives Phase-III drugs a stronger foundation for approval and commercial launch. They can rapidly attain widespread physician prescription and patient acceptance due to demonstrated clinical benefits and risk-mitigation.

Moreover, Phase-III trials involve partnerships with leading healthcare providers and medical centers to facilitate broad recruitment. This helps evaluate drugs in a real-world setting over longer duration and diverse patient groups. The data generated buttresses marketing campaigns targeting prescribing habits of physicians. Marketing teams can communicate well-researched quantitative and qualitative efficacy parameters to clinicians. This persuasive evidence boosts prescription volumes, especially for first-in-class therapies addressing unmet needs.

Additionally, Phase-III studies allow sponsors to file for expedited approvals like Priority Review or Breakthrough Therapy Designation. This shortens review timelines and speeds market entry. It also positions Phase-III drugs as the standard of care, encouraging doctors to prefer them over early phase alternatives. First-mover advantage is cemented through loyal patient followings and doctor-patient familiarity. Therefore, Phase-III represents the pinnacle of clinical proof, enabling market-leading positioning, sales momentum and commercial sustainability in pulmonary hypertension management.

Pulmonary Hypertension Drugs Market Segment Type

Insights, By Route of Administration, Accessibility is Expected to Drive Oral Route Dominance in the Forecast Period.

In terms of By Route of Administration, the oral route is expected to contribute the highest share 50.4% in 2024 due to unparalleled accessibility and comfort advantages over alternative pathways. Patients prefer oral medications as they are non-invasive and can be self-administered at home with minimal assistance. This ensures treatment adherence and compliance even in outpatient settings without physical monitoring.

Additionally, oral drugs have consistent, predictable absorption properties avoiding inter-patient variability seen with intravenous therapies. They provide stable, prolonged drug levels favorable for chronic indications like pulmonary hypertension. Oral formulations are also affordable, heat-stable and portable, allowing flexible dosing schedules wherever needed. This dosing autonomy supports active lifestyles and prevents disruption from therapy administration.

Physicians also favor the oral route as it streamlines outpatient care without recurrent clinic/hospital visits or skilled nursing for administration. Apart from convenience, it reduces infection risks and vascular access issues associated with intravenous therapies. Oral drugs eliminate painful injections or indwelling catheters, boosting patient satisfaction and quality of life. Their widespread use decreases clinic overhead costs as well. Therefore, the ubiquitous, non-invasive nature of oral delivery translates directly into higher market preference and consistency in pulmonary hypertension management.

Insights, By Molecule Type, Versatility of Small Molecules Drives Widespread Adoption in the Forecast Period.

In terms of By Molecule Type, small molecules contribute the highest share owing to their superior versatility in pulmonary hypertension treatment. Their low molecular weight allows utilization of multiple pathways for absorption including oral, inhalation and intravenous routes. This unmatched flexibility enables matching appropriate administration routes to individual patient needs and lifestyles.

Small molecule drugs also have well-established structure-activity relationships facilitating systematic optimization of pharmacological properties. Extensive medicinal chemistry helps enhance target affinity, selectivity and potency while maintaining safety. As a result, small molecules can be designed to achieve diverse mechanisms of action - from vasodilation to antiproliferative effects. This multimodal capability addresses pulmonary hypertension more comprehensively than monoclonal or biologic alternatives with narrower MOAs.

Additionally, small molecule synthesis enables large-scale, cost-effective manufacturing using proven technologies like organic synthesis. They have higher chemical and thermal stability than biologics, facilitating affordable mass production and longer shelf lives without refrigeration. These consistent production and supply chain advantages translate to widespread physician and patient access. It also allows small molecule combination therapies for augmented effectiveness.

Additional Insights of Pulmonary Hypertension Drugs Market

Pulmonary hypertension is a progressive and life-threatening condition characterized by increased blood pressure in the lungs. Despite advances in understanding the disease, current treatments remain limited, especially for advanced-stage patients. Novel therapies in the pipeline focus on addressing the underlying causes of pulmonary hypertension, such as improving vasodilation and targeting specific molecular pathways like soluble guanylate cyclase and nitric oxide signaling. Companies like Tenax Therapeutics, Bayer, and Atgeno AB are leading the charge with late-stage products that aim to improve patient outcomes by targeting multiple pathways simultaneously. With growing interest in gene therapy and small-molecule treatments, the pulmonary hypertension market is expected to see significant growth over the next decade as more therapies gain approval. The future of pulmonary hypertension treatment lies in a personalized approach that combines symptom management with disease-modifying therapies to improve long-term survival and quality of life for patients.

Competitive overview of Pulmonary Hypertension Drugs Market

The major players operating in the Pulmonary Hypertension Drugs Market include Tenax Therapeutics, Atgeno AB, Bayer, Bellerophon Therapeutics, United Therapeutics, Arena Pharmaceuticals, Acceleron Pharma, Altavant Sciences, Gossamer Bio, Actelion Ltd, Teva Pharmaceuticals, Steady Med Ltd, Eli Lilly and Company and Johnson & Johnson Services Inc.

Pulmonary Hypertension Drugs Market Leaders

  • Tenax Therapeutics
  • Atgeno AB
  • Bayer
  • Bellerophon Therapeutics
  • United Therapeutics
*Disclaimer: Major players are listed in no particular order.

Pulmonary Hypertension Drugs Market - Competitive Rivalry, 2024

Market Concentration Graph

Pulmonary Hypertension Drugs Market

Market Consolidated
(Dominated by major players)
Market Fragmented
(Highly competitive with lots of players.)
*Source: Coherent Market Insights

Recent Developments in Pulmonary Hypertension Drugs Market

  • In August 2024, Tenax Therapeutics announced the progression of TNX-103 into Phase III trials for pulmonary hypertension, demonstrating significant improvement in exercise capacity and symptom management.
  • In July 2023, Atgeno AB completed Phase II trials of PDNO, a first-of-its-kind intravenous drug utilizing nitric oxide to treat pulmonary hypertension, with promising results showing reduced pulmonary pressure.

Pulmonary Hypertension Drugs Market

  1. RESEARCH OBJECTIVES AND ASSUMPTIONS
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. MARKET PURVIEW
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Pulmonary Hypertension Drugs Market, By Stages
      • Pulmonary Hypertension Drugs Market, By Route of Administration
      • Pulmonary Hypertension Drugs Market, By Molecule Type
    • Coherent Opportunity Map (COM)
  3. MARKET DYNAMICS, REGULATIONS, AND TRENDS ANALYSIS
    • Market Dynamics
    • Impact Analysis
    • Key Highlights
    • Regulatory Scenario
    • Product Launches/Approvals
    • PEST Analysis
    • PORTER’s Analysis
    • Merger and Acquisition Scenario
  4. Global Pulmonary Hypertension Drugs Market, By Stages, 2024-2031, (USD Bn)
    • Introduction
      • Market Share Analysis, 2024 and 2031 (%)
      • Y-o-Y Growth Analysis, 2019 - 2031
      • Segment Trends
    • Phase-III
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Phase-II
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Phase-I
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Preclinical
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Discovery
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
  5. Global Pulmonary Hypertension Drugs Market, By Route of Administration, 2024-2031, (USD Bn)
    • Introduction
      • Market Share Analysis, 2024 and 2031 (%)
      • Y-o-Y Growth Analysis, 2019 - 2031
      • Segment Trends
    • Oral
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Intravenous
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Subcutaneous
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Parenteral
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
  6. Global Pulmonary Hypertension Drugs Market, By Molecule Type, 2024-2031, (USD Bn)
    • Introduction
      • Market Share Analysis, 2024 and 2031 (%)
      • Y-o-Y Growth Analysis, 2019 - 2031
      • Segment Trends
    • Small Molecules
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Monoclonal Antibody
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Peptides
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
    • Gene Therapy
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
  7. Global Pulmonary Hypertension Drugs Market, By Region, 2019 - 2031, Value (USD Bn)
    • Introduction
      • Market Share (%) Analysis, 2024,2027 & 2031, Value (USD Bn)
      • Market Y-o-Y Growth Analysis (%), 2019 - 2031, Value (USD Bn)
      • Regional Trends
    • North America
      • Introduction
      • Market Size and Forecast, By Stages, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Route of Administration, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Molecule Type, 2019 - 2031, Value (USD Bn)
        • U.S.
        • Canada
    • Latin America
      • Introduction
      • Market Size and Forecast, By Stages, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Route of Administration, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Molecule Type, 2019 - 2031, Value (USD Bn)
        • Brazil
        • Argentina
        • Mexico
        • Rest of Latin America
    • Europe
      • Introduction
      • Market Size and Forecast, By Stages, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Route of Administration, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Molecule Type, 2019 - 2031, Value (USD Bn)
        • Germany
        • U.K.
        • Spain
        • France
        • Italy
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Introduction
      • Market Size and Forecast, By Stages, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Route of Administration, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Molecule Type, 2019 - 2031, Value (USD Bn)
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • Introduction
      • Market Size and Forecast, By Stages, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Route of Administration, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Molecule Type, 2019 - 2031, Value (USD Bn)
        • GCC Countries
        • Israel
        • Rest of Middle East
    • Africa
      • Introduction
      • Market Size and Forecast, By Stages, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Route of Administration, 2019 - 2031, Value (USD Bn)
      • Market Size and Forecast, By Molecule Type, 2019 - 2031, Value (USD Bn)
        • South Africa
        • North Africa
        • Central Africa
  8. COMPETITIVE LANDSCAPE
    • Tenax Therapeutics
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Atgeno AB
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Bayer
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Bellerophon Therapeutics
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • United Therapeutics
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Arena Pharmaceuticals
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Acceleron Pharma
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Altavant Sciences
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Gossamer Bio
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Actelion Ltd
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Teva Pharmaceuticals
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Steady Med Ltd
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Eli Lilly and Company
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
    • Johnson & Johnson Services Inc
      • Company Highlights
      • Product Portfolio
      • Key Developments
      • Financial Performance
      • Strategies
  9. Analyst Recommendations
    • Wheel of Fortune
    • Analyst View
    • Coherent Opportunity Map
  10. References and Research Methodology
    • References
    • Research Methodology
    • About us

Pulmonary Hypertension Drugs Market Segmentation

  • By Stages
    • Phase-III
    • Phase-II
    • Phase-I
    • Preclinical
    • Discovery
  • By Route of Administration
    • Oral
    • Intravenous
    • Subcutaneous
    • Parenteral
  • By Molecule Type
    • Small Molecules
    • Monoclonal Antibody
    • Peptides
    • Gene Therapy
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Frequently Asked Questions :

How Big is the pulmonary hypertension drugs market?

The Global Pulmonary Hypertension Drugs Market is estimated to be valued at USD 8.10 bn in 2024 and is expected to reach USD 15.2 bn by 2031.

What will be the CAGR of the Pulmonary Hypertension Drugs Market?

What are the major factors driving the Pulmonary Hypertension Drugs Market growth?

What are the key factors hampering the growth of the Pulmonary Hypertension Drugs Market?

Which is the leading stage in the Pulmonary Hypertension Drugs Market?

Which are the major players operating in the Pulmonary Hypertension Drugs Market?